| 可生物降解长效缓释抗肿瘤药物的研究 |
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| 引用本文： | 程玲姝 徐若璞. 可生物降解长效缓释抗肿瘤药物的研究[J]. 合成化学, 1994, 2(1): 70-74 |
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| 作者姓名： | 程玲姝 徐若璞 |
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| 作者单位： | 中国科学院成都有机化学研究所 |
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| 摘 要： | 用铝复合催化剂合成了高分子量的ＰＬＡ，其降解寿命在十个月以上。进行了含有５－Ｆｕ抗肿瘤药物膜在生理盐水中的释放试验。结果表明，释放速度可通过改变共聚物的组成和成膜工艺来控制。
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| 关 键 词： | 生物降解 聚乳酸 抗癌药 长效缓释 |
Study on Biodegradable Long-Effective, Slow-Delivery, Anti-Cancer Drug |
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| Cheng Ling-Mei,Xu Ruo-Pu,Huang Hua-Hui,Xiong Cheng-Dong, Deng Xian-Mo. Study on Biodegradable Long-Effective, Slow-Delivery, Anti-Cancer Drug[J]. Chinese Journal of Synthetic Chemistry, 1994, 2(1): 70-74 |
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| Authors: | Cheng Ling-Mei Xu Ruo-Pu Huang Hua-Hui Xiong Cheng-Dong Deng Xian-Mo |
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| Abstract: | The polylaclide (PLA)of the high molecular weight has been synthesized with aluminium complex catalyst and the degradation life lasts over ten months. The drugdelivery of the membranes con taining anti-cancer 5-Fu in vitro has been oberved.Itshows that the delivery rate ean be controlled by changing the component of copolymerand the technlogy of drug membrane manufacturing. |
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| Keywords: | Long-effective Slow-delivery Biodegradable Polylaclide. |
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