Synthesis of 8-desbromohinckdentine A1 |
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Authors: | Liu Yahua McWhorter William W |
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Affiliation: | Medicinal Chemistry Research, Pharmacia Corporation, Kalamazoo, Michigan 49001, USA. |
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Abstract: | Hinckdentine A is an alkaloid isolated from the bryozoan Hincksinoflustra denticulate. This natural product contains a novel and unique 11b,12,13,14,15,16-hexahydroazepino[4',5':2,3]indolo[1,2-c]quinazoline ring system that has not previously been synthesized. We have synthesized 8-desbromohinckdentine A from a 2-aryl indole by first preparing the quaternary center of the natural product and then building the seven-membered lactam and dihydropyrimidine rings onto this intermediate to form the framework of hinckdentine A. |
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