Inclusion complexation of novocaine by beta-cyclodextrin in aqueous solutions |
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Authors: | Iglesias Emilia |
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Institution: | Departamento de Química Física e E. Q. I, Facultad de Ciencias, Universidad de La Coru?a, 15071-La Coru?a, Spain. qfemilia@udc.es |
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Abstract: | The formation of inclusion complexes between beta-cyclodextrin (beta-CD) and the local anesthetic 2-(diethylamino)ethyl-p-amino-benzoate (novocaine) in aqueous solutions under different acidity conditions, using steady-state fluorescence or UV-vis spectroscopies, electrical conductivity, or the kinetic study of both the nitrosation reaction of the primary amine group in a mild acid medium and the hydrolysis of the ester function under an alkaline medium, has been studied. The inclusion complex formation between neutral or protonated novocaine and beta-CD of 1:1 stoichiometry was observed; however, the magnitude of the binding constants depends on the nature of both the guest and the host, and the higher-affinity guest-host was found under conditions when both the novocaine and the beta-CD were neutral molecules. |
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