| 电场纺丝法制备药物缓释乙基纤维素纤维的研究 |
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| 引用本文： | 吴晓辉,王林格,黄勇.电场纺丝法制备药物缓释乙基纤维素纤维的研究[J].高分子学报,2006(2):264-268. |
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| 作者姓名： | 吴晓辉 王林格 黄勇 |
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| 作者单位： | 中国科学院广州化学研究所,纤维素化学重点实验室,广州,510650;中国科学院研究生院,北京,100039;中国科学院广州化学研究所,纤维素化学重点实验室,广州,510650;中国科学院广州化学研究所,纤维素化学重点实验室,广州,510650;中国科学院化学研究所,高分子物理与化学国家重点实验室,北京,100080 |
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| 基金项目： | 中国科学院优秀博士学位论文启动基金;中国科学院重点实验室基金 |
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| 摘 要： | 通过把四环素均匀分散在乙基纤维素溶液里,利用电场纺丝法制备了含有四环素的乙基纤维素超细纤维,并运用紫外-可见光分光度计测定了含四环素的乙基纤维素纤维在水中的释放曲线.发现用电场纺丝法制备的含四环素的纤维有良好的药物缓释作用,可以有效避免血液中药物浓度的“峰谷”现象的出现.纤维的直径以及药物在纤维中的浓度都会对四环素的释放效果产生影响,平均直径大的纤维的四环素的释放曲线增长的更为平稳,四环素含量高的纤维的释放曲线浓度高.
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| 关 键 词： | 电场纺丝法 乙基纤维素 超细纤维 药物释放 |
| 收稿时间： | 2004-10-26 |
| 修稿时间： | 2005-02-20 |
APPLICATION OF ELECTROSPUN ETHYL CELLULOSE FIBERS IN DRUG RELEASE SYSTEMS |
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| WU Xiaohui,WANG Linge,HUANG Yong.APPLICATION OF ELECTROSPUN ETHYL CELLULOSE FIBERS IN DRUG RELEASE SYSTEMS[J].Acta Polymerica Sinica,2006(2):264-268. |
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| Authors: | WU Xiaohui WANG Linge HUANG Yong |
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| Institution: | 1. Key Laboratory of Cellulose and Lignocellulosics Chemistry, Guangzhou Institute of Chemistry, Chinese Academy of Science, Guangzhou 510650;2 Graduate School of the Chinese Academy of Sciences, Beijing 100039;3 State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 |
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| Abstract: | Ethyl cellulose fibers containing tetracycline were produced by electrospinning,and the release process of tetracycline in aqueous solutions was measured and investigated by the ultraviolet-visible spectrometer method.It was found that the release of the tetracycline in water was delayed when the drug distributed inside the ethyl cellulose fiber.The drug delivery rate was controlled by the diameter of fibers and the tetracycline concentration in the fiber. The fiber with large diameter was better than that with small diameter in the controlled drug delivery. |
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| Keywords: | Electrospinning Ethyl cellulose Ultrathin fiber Drug delivery |
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