Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines |
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Authors: | Hu Libo Zhu Hui Du Da-Ming Xu Jiaxi |
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Affiliation: | Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. |
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Abstract: | Taurine and substituted taurines were synthesized efficiently from aziridines via ring-opening reaction with thioacetic acid, oxidation with performic acid, and hydrolysis in hydrochloric acid. The current method shows more benefit in purification and efficiency in the preparation of taurine and structurally diverse 2-substituted, 2,2-disubstituted, and 1,2-, 2,2-, and 2,N-alkylene taurines. |
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