An undecaprenyl phosphate analog containing the phenoxy group at the ω-end of the oligoisoprene chain |
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Authors: | Veselovsky V V Danilov L L Vinnikova A N Druzhinina T N |
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Institution: | 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation ; |
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Abstract: | A simple method for the preparation of a biologically active analog of bacterial undecaprenyl phosphate bearing the phenoxy
group at the ω-end of the chain was developed on the basis of accessible polyprenols from mulberry (Morus nigra) leaves. It includes the selective van Tamelen epoxidation of the ω-terminal isoprene unit of polyprenyl acetates, conversion
of the epoxides into ω-terminal aldehydes, their hydride reduction into hydroxy acetates followed by the Mitsunobu condensation
with phenol, and phosphorylation of the resulting phenoxy alcohols. The biological activity of the obtained phosphates was
tested by the radiometry method in the initiation of O-antigenic polysaccharide assembly reaction using the cell membrane
preparations from the Gram-negative bacteria Salmonella arizona O:59 and Aeromonas hydrophila AH-1. |
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