|
|||||
|
|
Enantioselective rhodium-catalysed addition of boronic acids using C2-symmetric aryl diphosphite ligands |
|
| Authors: | Christopher J Chapman Kelly J Wadsworth Christopher G Frost |
| Institution: | Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK |
| Abstract: | The enantioselective rhodium-catalysed conjugate addition of aryl boronic acids to dehydroalanine derivatives has been successfully carried out in the presence of C2-symmetric aryl diphosphite ligand (R,R,R-4) to prepare unnatural amino acid esters. The products have been obtained in up to 72% ee and with good isolated yield. |
| Keywords: | C---C coupling Amino acids Boronic acids Rhodium Conjugate addition |
| 本文献已被 ScienceDirect 等数据库收录！ | |