Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity |
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Authors: | WU Jian-feng TU Peng-fei ZHAN Hai-tao and GAO Jing-chun |
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Institution: | 1. College of Medicine, Foshan University, Foshan 528000, P. R. China;
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China;
3. Department of Biology and Chemistry, City University of Hongkong, Hong Kong SPR, P. R. China |
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Abstract: | Two new dioxyxanthones, polyhongkongenoxanthones A and B(1 and 2) were isolated from the herbs of Polygala hongkongensis, together with six known xanthones. Their structures were elucidated on the basis of chemical and spectroscopic evidence. The isolates were tested for their cytotoxicity against three tumor cell lines(HepG2, GLC-82 and MCF-7, HepG2=human hepatocellular carcinoma cells; GLC-82=human lung carcinoma cells; MCF-7= human breast carcinoma cells) by MTT assay, among which polyhongkongenoxanthone B(2), 1,7-dihydroxy-2,3- methylenedioxyxanthone(3) and 1,7-dihydroxy-3,4,8-trimethoxyxanthone(6) are potential antitumor candidate due to their significant cytotoxic effects on the three cell lines.. |
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Keywords: | Polygala hongkongensis Polygalaceae Dioxyxanthone Polyhongkongenoxanthone A and B Cytotoxicity |
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