Development of Electro Solid-Phase Microextraction and Application to Methamphetamine Analysis |
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Authors: | Dj Djozan T Baheri M H Pournaghi-Azar |
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Institution: | (1) Faculty of Chemistry, University of Tabriz, Tabriz, Iran |
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Abstract: | A new electro solid-phase microextraction (El-SPME) technique using homemade pencil-lead fibers has been developed as an effective
means of selective extraction of methamphetamine before analysis by gas chromatography (GC) and gas chromatography–mass spectrometry
(GC–MS). The methamphetamine was extracted by use of a laboratory-made El-SPME cell with three electrodes—the pencil-lead
SPME fiber, Ag/AgCl, and platinum as working, reference, and auxiliary electrodes, respectively. A negative potential was
applied to the homemade pencil-lead fiber during extraction. Experimental conditions, for example type of pencil-lead fiber,
conditions for modification of the fiber, extraction time, applied potential, pH, and gas chromatographic conditions were
optimized. Methamphetamine was identified by GC–MS. Screening of the extracted compounds showed that the proposed El-SPME
technique is much more selective than direct SPME using a commercially available polyacrylate fiber. Under the optimum conditions
the calibration plot for the compound was linear in the range 50–3,200 ng mL−1 and the detection limit was 34 ng mL−1. |
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Keywords: | Gas chromatography Gas chromatography– mass spectrometry Electro solid-phase microextraction Modified pencil-lead fiber Methamphetamine |
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