| Novel and Convenient Approach to Synthesis of AZT／d4T H-phosphonates |
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| 引用本文： | 林长学 付华 涂光忠 赵玉芬. Novel and Convenient Approach to Synthesis of AZT／d4T H-phosphonates[J]. 中国化学, 2004, 22(3): 225-227. DOI: 10.1002/cjoc.20040220302 |
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| 作者姓名： | 林长学 付华 涂光忠 赵玉芬 |
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| 作者单位： | [1]KeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation,DepartmentofChemistry,SchoolofLifeSciencesandEngineering,TsinghuaUniversity,Beijing100084,China [2]BeijingInstituteofMicrochemistry,Beijing100091,China |
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| 基金项目： | Project supported by Excellent Dissertation Foundation by the Chinese Ministry of Education (No. 200222). |
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| 摘 要： | A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions.
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| 关 键 词： | H-膦酸盐 AZT d4T 膦酸 三甲基乙酰氯 |
Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates |
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| LIN,Chang-Xuea) FU,Hua,a TU,Guang-ZhongbZHAO,Yu-Fen,a a Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education. Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates[J]. Chinese Journal of Chemistry, 2004, 22(3): 225-227. DOI: 10.1002/cjoc.20040220302 |
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| Authors: | LIN Chang-Xuea) FU Hua a TU Guang-ZhongbZHAO Yu-Fen a a Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of Education |
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| Affiliation: | LIN,Chang-Xuea) FU,Hua*,a TU,Guang-ZhongbZHAO,Yu-Fen*,a a Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education,Department of Chemistry,School of Life Sciences and Engineering,Tsinghua University,Beijing 100084,China b Beijing Institute of Microchemistry,Beijing 100091,China |
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| Abstract: | A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions. |
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| Keywords: | H-phosphonate AZT d4T phosphonic acid pivaloyl chloride |
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