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Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer |
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| Authors: | Ren Fei Li Zeshun Li Kai Zheng Xiaoyan Shi Jianbing Zhang Chen Guo Heng Tong Bin Xi Lei Cai Zhengxu Dong Yuping |
| Affiliation: | 1.Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081, China ;2.Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China ;3.Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China ; |
| Abstract: | Photothermal therapy(PTT) is emerging as an effective treatment for superficial carcinoma. A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency. Aiming to address this challenge, we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers. Among these multi-arylpyrrole derivatives, MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%) when they are encapsulated by an amphiphilic polymer. As a result, the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic signals. The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors. |
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