杯芳烃和柱芳烃桥梁部位的衍生及其功能化

随着大环化学的快速发展,对杯芳烃、柱芳烃及其他类似化合物的桥梁亚甲基部位进行高效修饰的方法日益引起人们的关注.桥梁部位修饰后的大环衍生物,在不改变其原有属性的基础上增加了新的功能,不仅可以引入更多的功能基团,而且可以通过主客体的自组装行为,进一步拓展杯芳烃和柱芳烃等超分子大环在药物递送、化学传感、荧光体系构建等诸多领域的应用.本文对杯芳烃和柱芳烃桥梁部位修饰的研究进展进行了综述.按照修饰方法的不同进行分类,系统阐述了杯芳烃和柱芳烃桥梁部位修饰的方法、修饰后结构的变化,以及相应的应用拓展,并进一步讨论了其未来发展所面临的机遇与挑战.

Meso position functionalized calix[n]arenes and pillar[n]arenes and their applications

With the rapid development of macrocyclic chemistry, the functionalization of calixn]arenes, pillarn]arenes and other methylene linked macrocycles at their meso positions has drawn much attention. These modified macrocyclic derivatives have new functions on the basis of not changing their original properties. Not only more functional groups can be introduced, but also their applications, such as drug delivery, chemical detection, fluorescent system fabrication,are further improved due to the self-assembly behavior of host and guest. Based on the comprehensive analysis of the current research on the modification of calixn]arenes and pillarn]arenes at meso position, this review systematically summarizes the modification methods, the changes of the modified structures, and applications. The opportunities and challenges of its future development have been discussed.