Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group |
| |
Authors: | Mijoon Lee Dusan Hesek Bruce C. Noll Shahriar Mobashery |
| |
Affiliation: | (1) Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA |
| |
Abstract: | Dimethylmaleoyl (DMM) moiety has become an important amine protective group in sugar chemistry. We disclose herein that DMM-containing D-glucosamine analogues, because of their electrophilic nature, are prone to reactions with strong nucleophiles, such as hydrazine, resulting in a set of undesired side products that are difficult to detect, yet proved to be problematic for organic synthesis. |
| |
Keywords: | amine protective group dimethylmaleoyl glucosamine carbohydrate peptidoglycan |
本文献已被 SpringerLink 等数据库收录! |
|