| 聚磷酸酯—聚氨酯药物释放材料的合成 |
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| 引用本文： | 卓仁禧 王均. 聚磷酸酯—聚氨酯药物释放材料的合成[J]. 高等学校化学学报, 1997, 18(7): 1207-1211 |
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| 作者姓名： | 卓仁禧 王均 |
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| 作者单位： | 武汉大学化学系，国家教育委员会生物医用高分子材料开放实验室，!武汉，430072，武汉大学化学系，国家教育委员会生物医用高分子材料开放实验室，!武汉，430072，武汉大学化学系，国家教育委员会生物医用高分子材料开放实验室，!武汉，430072 |
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| 摘 要： | 报道了一类新型生物可降解和生物相容性药物释放材料聚磷酸酯－聚氨酯的合成和表征，研究了这类聚合物的体外降解及其对牛血清白蛋白的释放性能。
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| 关 键 词： | 聚磷酸酯 聚氨酯 药物释放材料 PPU |
Syntheses of Poly(phosphate-urethane)s as Drug Release Materials |
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| ZHUO Ren-Xi, WANG Jun, MAO Hai-Quan. Syntheses of Poly(phosphate-urethane)s as Drug Release Materials[J]. Chemical Research In Chinese Universities, 1997, 18(7): 1207-1211 |
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| Authors: | ZHUO Ren-Xi WANG Jun MAO Hai-Quan |
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| Abstract: | New biodegradable and biocompatible copolymers poly (phosphate-urethane ) swith elevated molecular weight were synthesized by the polycondensation of Ser-Tyr orTyr-Tyr dipeptide and phosphorodichloridate and followed by reacting with 1,4-butane-di-isocyanate. The chemical structures were confirmed by 1H NMR, FTIR and elemental analy-sis. The molecular weight, and thermostability of these polymers were investigated. The invitro degradation and bovine serum albumin (BSA) release profile were also studied. It wasfound that the degradation rate of the materials and BSA release behavior can be modulatedby varying the hydrohobic properties of these poly(phosphate-urethane)s. |
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| Keywords: | Poly(phosphate-urethanes) Biodegradable property Biocompatibility Drug re-lease materials |
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