Novel synthesis of the C1-C15 polyether domain of the thyrsiferol and venustatriol natural products |
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Authors: | González I C Forsyth C J |
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Institution: | Department of Chemistry, University of Minnesota, Minneapolis 55455, USA. |
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Abstract: | formula: see text] A convergent construction of the C1-C15 domain of the thyrsiferol-related natural products has been developed. This involved the separate construction of C1-C7 and C8-C15 fragments, their organochromic-mediated coupling, and subsequent reductive closure of the B ring. This synthetic A-B-C ring construct will be useful for the total synthesis of the biologically active polyether squalenoid natural products, as well as their non-natural analogues. |
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