Studies on the synthesis of tedanolide: synthesis of the C(5)-C(21) segment via a highly stereoselective fragment assembly aldol reaction of a chiral beta,gamma-unsaturated methyl ketone |
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| Authors: | Roush W R Lane G C |
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| Institution: | Department of Chemistry, University of Michigan, Ann Arbor 48109, USA. roush@umich.edu |
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| Abstract: | formula: see text] A highly diastereoselective synthesis of 3, corresponding to the C(5)-C(21) segment of tedanolide, has been accomplished by a route utilizing the aldol reaction of aldehyde 4 and the beta,gamma-unsaturated methyl ketone 5. |
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