Gelatin‐based photopolymers for bone replacement materials |
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| Authors: | Monika Schuster Claudia Turecek Guenter Weigel Robert Saf Juergen Stampfl Franz Varga Robert Liska |
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| Affiliation: | 1. Institute of Applied Synthetic Chemistry, University of Technology, Vienna, Austria;2. Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria;3. Ludwig‐Boltzmann Cluster for Cardiovascular Research, Medical University, Vienna, Austria;4. Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria;5. Institute of Materials Science and Technology, University of Technology, Vienna, Austria |
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| Abstract: | Gelatin‐based monomers were considered as suitable base component for the 3D structuring of potential bone replacement materials by stereolithographic techniques. Different methacrylate‐based gelatin derivatives were prepared, whereas a polyethylene glycol modified derivative GP4M turned out to have the highest tolerance toward other monomers. These are essential as they allow the tuning of the photoreactivity and the mechanical properties. Cell culture experiments with osteoblast‐ and endothelial‐like cells confirmed negligible cytotoxicity of these monomers. Finally, we were able to show the possibility of producing arbitrary cellular structures with these gelatin‐containing formulations using stereolithography. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2009 |
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| Keywords: | biomaterials bone tissue engineering gelatine photopolymerization radical polymerization stereolithography |
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