One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water |
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| Authors: | Abbas Muhammad Bethke John Wessjohann Ludger A |
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| Affiliation: | Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. |
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| Abstract: | Selenocysteine containing peptoids and peptide-peptoid conjugates were synthesized by combinatorial Ugi-MCRs (multicomponent reactions) in water: for the first time, an acetal (selenoacetal 2a) was used in Ugi-MCR to furnish selenocysteine peptoids in one step as model compounds for selenocysteine peptides and proteins. |
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