Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products |
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| Authors: | Judyta Cielecka-Piontek Aran Lunzer Anna Jelińska |
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| Institution: | (1) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland |
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| Abstract: | A first-derivative UV spectrophotometric method, with or without the subtraction technique, was developed for the determination
of biapenem in pharmaceutical dosage form in the presence of its degradation products. The method was based on the measurement
of first-derivative amplitudes at zero crossing point (λ = 312 nm) and the peak-to-zero technique and validated with regard
to linearity, limits of detection and quantitation, selectivity and precision. The observed rate constants for the degradation
of biapenem were comparable to those obtained in the stability-indicating HPLC method.
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