Convenient synthesis of chiral H4-BINOL via direct hydrogenation of BINOL |
| |
Authors: | Qian Chang Ding Yun Feng Du Xin Sheng Li Dong Cheng Xu |
| |
Affiliation: | Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, 321004, China |
| |
Abstract: | A simple, highly effective hydrogenation of chiral BINOL to provide H4-BINOL in multigram scale with good yield (up to 78% yield) was developed. A series of heterogeneous catalysts were tested in the hydrogenation; the best result was obtained with 5% Pd/C in EtOH under the H2 pressure of 50 bar for 2h. This method is a more useful method for practical synthesis of optically pure H4-BINOL than other available methods. |
| |
Keywords: | Hydrogenation 1,1-Bi-2-naphthol 5,6,7,8-Tetrahydro-1,1-bi-2-naphthol Chiral Pd/C |
本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|