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Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid |
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| Authors: | Sharon M. Dankwardt Thu M. Phan John L. Krstenansky |
| Affiliation: | (1) Chemical Research and Development, Syntex Discovery Research, 3401 Hillview Avenue, 94304 Palo Alto, CA, USA;(2) Present address: Affymax Research, 4001 Miranda Avenue, 94304 Palo Alto, CA, USA |
| Abstract: | Summary A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted. |
| Keywords: | Solid-phase synthesis Combinatorial approach Non-peptide library 3-Amino-5-hydroxybenzoic acid |
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