Design,synthesis, preliminary pharmacological evaluation,and docking studies of pyrazoline derivatives |
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Authors: | Nirupam Das Biswajit Dash Meenakshi Dhanawat Sushant Kumar Shrivastava |
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Institution: | (1) Faculty of Pharmacy, Department of Pharmacology, Anadolu University, 26470 Eskişehir, Turkey;(2) Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, Turkey; |
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Abstract: | Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were synthesised from chalcone-like
intermediate and substituted phenyl hydrazines, hydrazine hydrate, and semi/thiosemicarbazide. The chemical structure of compounds
was confirmed by means of IR, 1H NMR, mass spectroscopy, and elemental analysis. The antidepressant and anticonvulsant activities were investigated by Porsolt’s
behavioural despair test (forced swimming) and maximum electroshock seizure test, respectively. Rota-Rod test was performed
to assess any probable changes in motor coordination induced by the test compounds. Four compounds (IId, IIg, IIi, and IIj) exhibited good activity profile against depression and docking studies confirmed their consensual interaction with monoamine
oxidase A. In addition, compounds IIc and IIe showed protection against MES-induced seizures. |
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Keywords: | |
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