Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites |
| |
| Authors: | Kakeya Hideaki Onose Rie Koshino Hiroyuki Yoshida Arika Kobayashi Kimiko Kageyama Shun-Ichiro Osada Hiroyuki |
| |
| Institution: | Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. |
| |
| Abstract: | A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
