A coupled two-compartment model for immobilized enzyme electrodes

The effect of stirring on the transient and pseudo steady-state behavior of potentiometric and amperometric immobilized enzyme electrodes is accurately modelled by a coupled two-compartment system of nonlinear differential equations. In the first compartment, the enzyme layer, the chemistry is governed by enzyme kinetics and diffusion. This is coupled to the second compartment, the bulk solution, which is controlled only by molecular diffusion. Several results of analytical significance can be obtained by using this model: for example, it is shown how the stirring rate can be used to increase the linear dynamic range.