New route for the synthesis of benzimidazoles by a one-pot multistep process with mono and bifunctional solid catalysts |
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Authors: | Violeta R. Ruiz,Marí a J. Sabater |
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Affiliation: | Instituto de Tecnología Química UPV-CSIC, Avenida Los Naranjos s/n, 46022 Valencia, Spain |
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Abstract: | One-pot multistep reactions involving a new environmentally friendly catalytic procedure have been developed for the synthesis of benzimidazoles. Benzimidazole derivatives with biological and pharmaceutical interest have been prepared by a one-pot four step process with a solid catalyst containing basic and oxidation sites. The four steps refer to: (a) oxidation of the alcohol; (b) cyclocondensation of the aldehyde formed with ortho-phenylenediamines, (c) oxidation of the carbon-nitrogen bond, (d) N-alkylation reaction. The process is illustrated by the synthesis of 1,2-disubstituted benzimidazole derivative with antiviral activity. |
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Keywords: | One-pot Benzimidazole Heterogeneous Aerobic oxidation Gold Palladium |
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