Convergent synthesis of the tetrasaccharide repeating unit related to the O-antigenic polysaccharide of Escherichia coli 78 |
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Authors: | Sajal K Maity Rina Ghosh |
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Institution: | a Department of Chemistry, Jadavpur University, Kolkata 700 032, India b Department of Chemistry, University College of Science and Technology, University of Calcutta, Kolkata 700 009, India |
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Abstract: | A convergent synthesis of the tetrasaccharide repeating unit of the O-antigenic cell wall polysaccharide of Escherichia coli 78, as the corresponding methyl glycoside (I), is being reported. It involved stereoselective glycosidation of a β-linked mannodisaccharide acceptor with a β-linked glucosamine based disaccharide thioglycoside donor, which were prepared from the corresponding functionalised monosaccharide based glycosyl donors and acceptors. The resulting tetrasaccharide derivative was finally converted to (I) by selective deprotection and also by global protection and deprotection techniques. |
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Keywords: | E coli 78 O-Antigen Tetrasaccharide Cell wall polysaccharide |
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