Synthesis of the cyclic heptapeptide axinellin A |
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Authors: | Kelly A. Fairweather Christos Roussakis |
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Affiliation: | a School of Chemistry, The University of Sydney, 2006 NSW, Australia b Faculté de Pharmacie, 1 Rue Gaston Veil, F-044035 Nantes Cedex 01, France |
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Abstract: | The first synthesis of the naturally occurring cyclic peptide axinellin A has been achieved. Cyclization and subsequent deprotection of linear precursors containing either a t-butyl protected Thr residue or a Thr(ΨMe,Mepro) derivative gave a cyclic peptide, identical in all respects to the naturally occurring material, with the exception that the synthetic peptide does not exhibit the cytotoxic activity reported for the natural product. |
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Keywords: | Cyclic peptide Pseudoproline Cyclization Natural product |
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