Enantioselective CD analysis of amino acids based on chiral amplification with a stereodynamic probe |
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Authors: | Marwan W. Ghosn |
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Affiliation: | Department of Chemistry, Georgetown University, Washington, DC 20057, USA |
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Abstract: | The condensation between stereolabile 1,8-bis(3′-formyl-4′-hydroxyphenyl)naphthalene, 1, and two amino acid molecules results in the formation of chiral diimines exhibiting strong CD signals. This reaction has been used to develop a chiroptical sensing method for the determination of the absolute configuration and enantiomeric composition of unprotected amino acids. This sensing approach is based on distinctive chiral amplification due to central-to-axial chirality induction within the diimine scaffold formed and does not require the use of an enantiopure ligand or metal complex. |
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Keywords: | Amino acids Sensing Chiral amplification Circular dichroism Dynamic stereochemistry |
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