Intramolecular reductive amination strategy to the synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-2-benzylmorpholine |
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| Authors: | Rajiv T Sawant |
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| Institution: | Department of Chemistry, University of Pune, Ganeshkhind Road, Pune 411 007, Maharashtra, India |
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| Abstract: | A concise high yielding enantioselective synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-benzylmorpholine has been achieved by employing proline-catalyzed asymmetric α-aminooxylation of aldehyde and palladium-catalyzed intramolecular reductive amination of azido aldehyde as the key steps. |
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| Keywords: | Proline Asymmetric α-aminooxylation Morpholines Pharmacologically active Reductive amination |
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