Chemical reactivity of 6-diazo-5-oxo-l-norleucine (DON) catalyzed by metalloporphyrins (Fe,Ru) |
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| Authors: | Paul Le Maux |
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| Affiliation: | Ingénierie Chimique et Molécules pour le Vivant, UMR CNRS 6226, Campus de Beaulieu, Université de Rennes 1, 35042 Rennes, France |
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| Abstract: | The transfer of the metallocarbene derived from N- and O-protected 6-diazo-5-oxo-l-norleucine (DON) catalyzed by metalloporphyrins undergoes dimerization, cyclopropanation, N-H and S-H insertion reactions, respectively. An efficient and direct synthesis of 5-oxo-l-pipecolic acid from DON is described from unprotected 6-diazo-5-oxo-l-norleucine. |
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| Keywords: | 6-Diazo-5-oxo- smallcaps" >l-norleucine Ruthenium porphyrin Iron porphyrin Catalytic carbene transfer |
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