The synthesis of morusin as a potent antitumor agent |
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| Authors: | Tsui-Hwa Tseng Shien-Kai Chuang Chia-Fu Chang Cheng-Wei Lin |
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| Affiliation: | a School of Applied Chemistry, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo N. Road, Taichung 402, Taiwan
b Department of Chemistry, National Changhua University of Education,1 Ching Der Road, Changhua 50058, Taiwan |
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| Abstract: | Morusin, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol. In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described. Consequently, this strategy provided a concise route to synthesize the morusin analogues as well. Further biological studies of morusin, it exhibited strong antitumor effects with IC50 ∼3.0 μM on three cancer cells. |
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| Keywords: | Morusin EtSLi SnCl2 |
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