Chemoenzymatic synthesis of symmetrically structured triacylglycerols possessing short-chain fatty acids |
| |
Authors: | Carlos D. Magnusson |
| |
Affiliation: | Science Institute, University of Iceland, Dunhaga 3, 107 Reykjavik, Iceland |
| |
Abstract: | Synthesis of symmetrically structured triacylglycerols possessing bioactive n−3 polyunsaturated fatty acids (eicosapentaenoic acid or docosahexaenoic acid) at the 2-position and a short-chain fatty acid (C2, C4, C6) located at the end-positions by a highly efficient two-step chemoenzymatic process is described. Full regiocontrol devoid of any acyl-migration side reactions was obtained in both a lipase promoted step to introduce the short-chain fatty acids exclusively into the primary alcohol positions of glycerol using activated vinyl esters at low temperature and a subsequent coupling reaction involving free EPA and DHA using EDAC as a coupling agent. |
| |
Keywords: | Lipase regioselectivity Structured triacylglycerols Regiocontrol n&minus 3 PUFA |
本文献已被 ScienceDirect 等数据库收录! |
|