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Total synthesis of 3,3-difluorinated 1-deoxynojirimycin analogues |
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| Authors: | René Csuk,Erik Prell,Claudia Korb,Ralph Kluge,Dieter Strö hl |
| Affiliation: | Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany |
| Abstract: | Difluorination of 1-deoxynojirimycin at position C(3) creates a competitive inhibitor 15 of 10 times higher activity against an α-glucosidase than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations. |
| Keywords: | 1-Deoxynojirimycin Difluorination α-Glucosidase inhibitor α-Galactosidase inhibitor |
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