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Efficient construction of functionalized 5-carboxymethyl tetramic acids using N-Ac-l-aspartic anhydride as chiral building block |
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| Authors: | Kyriakos C Prousis Vickie Mckee |
| Institution: | a National Technical University of Athens, School of Chemical Engineering, Laboratory of Organic Chemistry, Zografou Campus, Heroon Polytechniou 9, Athens 15773, Greece b University of Athens, Department of Chemistry, Laboratory of Inorganic Chemistry, Panepistimiopolis Zografou, Athens 15771, Greece c University of Loughborough, Chemistry Department, Leicestershire LE113TU, UK |
| Abstract: | A novel method for the synthesis of densely functionalized optically active 5-carboxymethyl tetramic acids is reported. The proposed strategy is focused on the synthesis of 3,3′-disubstituted pyrrolidine-2,4-diones as useful molecules for the synthesis of natural products. The proposed methodology has been established by X-ray diffraction structure analysis. |
| Keywords: | Tetramic acids l-Aspartic anhydride" target="_blank">l-Aspartic anhydride Lithium enolates 3 3&prime -Disubstituted pyrrolidine-2 4-diones C-acylation |
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