Synthesis of highly functionalized β-lactam substituted pyrroloisoquinoline and indolizinoindole system by sequential intermolecular 1,3-dipolar cycloaddition reaction and Pictet-Spengler cyclization |
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Authors: | Natarajan Arumugam |
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Institution: | Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India |
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Abstract: | Synthesis of novel pyrroloisoquinoline and indolizinoindole derivatives with β-lactam unit has been achieved by sequential intermolecular 1,3-dipolar cycloaddition reaction and Pictet-Spengler cyclization. The azomethine ylide derived from β-lactam imine of α-amino ester in the presence of silver acetate reacted with nitrostyrenes to give pyrrolidinyl β-lactam, which underwent Pictet-Spengler cyclization in presence of trifluoroacetic acid to give pyrroloisoquinolines and indolizinoindoles. |
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Keywords: | 1 3-Dipolar cycloaddition β-Lactam Pyrroloisoquinoline Indolizinoindole Pictet-Spengler cyclization |
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