Total synthesis of neopeltolide and analogs |
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Authors: | Yubo Cui |
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Affiliation: | Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA |
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Abstract: | Neopeltolide, a potent cytotoxin from a Carribean sponge, was synthesized through a brief sequence that highlights the use of ethers as oxocarbenium ion precursors. Other key steps include an acid-mediated etherification and sequence that features a Sonogashira reaction, an intramolecular alkyne hydrosilylation reaction, and a Tamao oxidation. The alkene that is required for the oxidative cyclization can be hydrogenated to provide access to the natural product or an epimer, or can be epoxidized or dihydroxylated to form polar analogs. |
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Keywords: | Synthesis Cations Macrocycles Oxidation Analogs |
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