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Straightforward stereoselective synthesis of polyfunctionalised cyclohexenols using a multicomponent approach |
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| Authors: | Andrea Basso Luca Banfi Giuseppe Guanti Renata Riva |
| Institution: | Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale. Via Dodecaneso 31, 16146 Genova, Italy |
| Abstract: | An intramolecular Ugi 5-centre-4-component reaction (U-5C-4CR) followed by a palladium-catalysed ring-opening has been employed to transform oxabicycloheptene-based β-amino acids into two families of regioisomeric polyfunctionalised cyclohexenols. The whole process is completely stereoselective and enantiomerically pure products are obtained in high overall yields. |
| Keywords: | Cyclohexenols Multicomponent reactions Norbornenyl amino acids Ring-opening reactions Enantioselective synthesis Diversity oriented synthesis |
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