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An enantioselective total synthesis of (S)-(−)-licochalcone E: determination of the absolute configuration |
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| Authors: | Zhiguo Liu Seung Hoon Cheon |
| Institution: | a College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, Republic of Korea b Korea Institute of Science and Technology, Gangneung Institute, Gangneung 210-340, Republic of Korea |
| Abstract: | The absolute configuration of (−)-licochalcone E (1) was determined to be (S) via the first enantioselective total synthesis of the compound. The chirality in (S)-(−)-licochalcone E (1) was installed by asymmetric methylation of the Evans' oxazolidinone derivatives. |
| Keywords: | Enantioselective synthesis Licochalcone E Asymmetric methylation Chiral oxazolidinone |
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