The enantioselective intramolecular Morita-Baylis-Hillman reaction catalyzed by amino acid-derived phosphinothiourea |
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| Authors: | Jing-Jing Gong |
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| Affiliation: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | A series of chiral bifunctional phosphinothioureas derived from l-amino acids have been developed to promote the enantioselective intramolecular Morita-Baylis-Hillman reaction. The process afforded the cyclic hydroxyl enones with up to 84% ee and good yields under mild conditions. |
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| Keywords: | Enantioselective organocatalysis Intramolecular Morita-Baylis-Hillman reaction Chiral phosphinothiourea Amino acids Enones |
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