Total synthesis of (−)-codonopsinol and (+)-2-epi codonopsinol via acid catalyzed amido cyclisation |
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| Authors: | Y. Jagadeesh B. Venkateswara Rao J. Lakshmi Swarnalatha |
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| Affiliation: | a Organic Division III, Indian Institute of Chemical Technology, Hyderabad 500607, India
b Bio-transformations laboratory, Indian Institute of Chemical Technology, Hyderabad 500607, India |
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| Abstract: | A short and stereoselective synthesis of (−)-codonopsinol 5 and its C-2 epimer 6 were accomplished from commercially available starting material d-1,5-gluconolactone, using acid mediated amido cyclisation as the key step. The inhibitory activitiy of these compounds against glucosidase and galactosidase has been studied. |
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