Ethynyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis |
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| Authors: | Justin R. Struble |
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| Affiliation: | Howard Hughes Medical Institute, Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA |
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| Abstract: | Ethynyl N-methyliminodiacetic acid (MIDA) boronate is a very useful building block for small molecule synthesis. This compound can serve as both a bifunctional acetylene equivalent with the capacity for terminus-selective bis-functionalization and a versatile starting material for the preparation of a wide range of other MIDA boronate building blocks. |
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| Keywords: | MIDA boronates Iterative cross-coupling Small molecule synthesis Alkynes Sonogashira coupling Diels-Alder |
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