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A convenient approach towards 2- and 3-aminobenzo[b]thiophenes |
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| Authors: | Dmitry A Androsov Andrey Y Solovyev Ray J Butcher |
| Institution: | a Department of Organic Chemistry, Saint-Petersburg State Institute of Technology, Moskovskii prospekt 26, Saint-Petersburg 190013, Russian Federation b Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA c Department of Chemistry, Howard University, Washington, DC 20059, USA d Department of Chemistry, Keene State College, Keene, NH 03435, USA |
| Abstract: | Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler route with primary or secondary amines and sulfur allows a simple, efficient one-pot synthesis of 3-aminobenzob]thiophenes. Base-catalyzed transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of primary and secondary amines offers a convenient approach towards 2-aminobenzob]thiophenes. |
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