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Squaraine-based colorimetric and fluorescent sensors for Cu-specific detection and fluorescence imaging in living cells |
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| Authors: | Weida Wang Jingsong You Ge Gao Lijuan Chen |
| Institution: | a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China b State Key laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Keyuan Road 4, Gaopeng Street, Chengdu 610041, PR China |
| Abstract: | New squaraine-based chemosensors SQ1 and SQ2 functionalized with 2-picolyl units were first synthesized and used as highly selective and sensitive colorimetric and fluorometric dual-channel sensors for Cu2+-specific recognition in aqueous systems. Among a series of individual metal ions, only Cu2+ could result in dramatic color changes. We also evaluated their capability of biological applications and found that SQ2 could be successfully employed as a Cu2+-selective probe in the fluorescence imaging of living cells. |
| Keywords: | Colorimetric chemosensor Squaraine Copper ion Fluorescent probe Imaging agents |
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