Catalytic asymmetric synthesis of cyclic α-alkyl-amino acid derivatives by C,N-double alkylation |
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| Authors: | Taichi Kano |
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| Institution: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan |
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| Abstract: | Catalytic asymmetric synthesis of various cyclic α-alkyl-amino acid derivatives having a tetrasubstituted α-carbon, such as α-alkylprolines has been accomplished by asymmetric phase-transfer C-alkylation of α-alkyl-amino acid derivatives and subsequent intramolecular N-alkylation. |
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| Keywords: | Asymmetric synthesis Amino acid Phase-transfer catalyst Alkylation Cyclization |
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