Efficient macrocyclization using methylene-tethered terminal dienes and bis(manganese(III)-enolate)s |
| |
Authors: | Yosuke Ito |
| |
Institution: | Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kurokami 2-39-1, Kumamoto 860-8555, Japan |
| |
Abstract: | Macrocyclic compounds, which have two fused dihydrofuran rings, were synthesized with complete control by the oxidation of α,α,ω,ω-tetraaryl-α,(ω-1)-alkadienes 1x with manganese(III)-oligomethylenebis(enolate) complexes directly formed by the reaction of the oligomethylene bis(3-oxobutanoate)s 2y with manganese(III) acetate in situ. The oxamethylene-tethered macrodiolides 5 and 7 were also produced in good to moderate yields by a similar oxidation. The key intermediate, an electron donor-acceptor-like complex, was proposed for the efficient macrocyclization reaction. |
| |
Keywords: | Macrocyclization Oxidation Electron donor-acceptor complex Manganese(III) acetate Macrocyclic compounds |
本文献已被 ScienceDirect 等数据库收录! |
|