Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition |
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| Authors: | Cao Xiaohui Wang Ge Zhang Richeng Wei Yingying Wang Wei Sun Huichao Chen Ligong |
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| Institution: | School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China. |
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| Abstract: | A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature. |
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