Titanium-mediated cross-coupling reactions of imines with ketones or aldehydes: an efficient route for the synthesis of 1,2-amino alcohols |
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| Authors: | Guoqin FanYuanhong Liu |
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| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People’s Republic of China |
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| Abstract: | The cross-coupling reactions of imines with ketones using Ti(OiPr)4/c-C5H9MgCl reagent lead to 1,2-amino alcohols after hydrolysis. The coupling reactions with aldehydes could also afford 1,2-amino alcohols, however, in some cases, aziridines were obtained as major products in a stereoselective manner. |
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| Keywords: | Titanium-imine complex Azatitanacyclopropane Coupling Ketones and aldehydes 1 2-Amino alcohol |
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