Efficient synthesis and applications of 2-substituted azulene derivatives: towards highly functionalized carbo- and heterocyclic molecules |
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| Authors: | Chi-Phi Wu Badugu DevendarHui-Chi Su Ya-Hui ChangChien-Kuo Ku |
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| Affiliation: | a Department of Chemistry, Chung Yuan Christian University, Chungli 32023, Taiwan
b Department of Applied Physics and Chemistry, Taipei Municipal University of Education, Taipei 10042, Taiwan |
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| Abstract: | An efficient synthesis of 2-substituted azulene derivatives (3-6) was accomplished from ethyl 2-oxo-2H-cyclohepta[b]furan-3-carboxylate 1 and its derivative 2, which in turn were prepared from readily available tropolone. Compounds 1 and 2 were utilized to construct densely functionalized benz[a]azulene and azulene-furan frameworks (16-25, 29-34, 37, 38). |
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| Keywords: | Azulenes Electrophilic substitution reactions Aldol reactions Paal-Knorr furan synthesis Carbo- and heterocyclic molecules |
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