Exploration of copper and amine-free Sonogashira cross coupling reactions of 2-halo-3-alkyl imidazo[4,5-b]pyridines using tetrabutyl ammonium acetate as an activator under microwave enhanced conditions |
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| Authors: | Ayyiliath M Sajith |
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| Institution: | a Organic Chemistry Division, School of Chemical Sciences, Kasargod Govt. College, Kannur University, Kasargod, India
b Organic Chemistry Division, School of Chemical Sciences, Nehru Arts and Science College, Kannur University, Kannur, India |
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| Abstract: | Enhancing the reactivity of the catalytic system by using palladium catalyst with sterically demanding and electron rich ligands attached to it has often been shown as an appropriate way of performing the copper-free Sonogashira reaction. In this paper, we report PdCl2(PCy3)2 as an efficient catalyst for the copper and amine-free Sonogashira cross coupling reactions of 2-halo-3-alkyl imidazo4,5-b]pyridines (I, Br, Cl) using tetrabutyl ammonium acetate as an activator under microwave enhanced conditions. |
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| Keywords: | Microwave Sonogashira coupling Imidazo[4 5-b]pyridine |
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