| 原发性肝癌P53基因第249密码子突变的研究 |
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| 引用本文： | 杨定华,林伟雄,李绍森,卢全书,姜海行,卢榜裕,王文光,冯穗生,刘家奇,彭民浩.原发性肝癌P53基因第249密码子突变的研究[J].广西科学,1995,2(1):58-59. |
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| 作者姓名： | 杨定华 林伟雄 李绍森 卢全书 姜海行 卢榜裕 王文光 冯穗生 刘家奇 彭民浩 |
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| 作者单位： | 广西医科大学第一附属医院 |
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| 摘 要： | 用聚合酶链反应－限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）技术对７例原发性肝细胞癌（ＰＨＣ）进行Ｐ＾５３基因第２４９密码子突变的检测。结果：７例肝细胞癌中３例有Ｐ＾５３基因第２４９密码子突变，突变率达４２．９％。
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| 关 键 词： | 肝细胞癌 P^53基因 PCR－RFLP 突变 |
| 收稿时间： | 1994/12/24 0:00:00 |
The Mutation at Codon 249 of the P53 Gene in Primary Hepatocellular Carcinoma |
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| Yang Dinghu,Lin Weixiong,Li Shaosheng,Lu Quanshu,Jiang Haixing,Lu Bangyu,Wang Wenguang,Fong Shuisheng,Lin Jiaqi and Peng Minghao.The Mutation at Codon 249 of the P53 Gene in Primary Hepatocellular Carcinoma[J].Guangxi Sciences,1995,2(1):58-59. |
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| Authors: | Yang Dinghu Lin Weixiong Li Shaosheng Lu Quanshu Jiang Haixing Lu Bangyu Wang Wenguang Fong Shuisheng Lin Jiaqi and Peng Minghao |
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| Institution: | Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021,Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021 and Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021 |
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| Abstract: | Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to examine the mutation at codon 249 of the P53 gene in 7 cases of primary hepatocellular carcinoma. The mutation at codon 249 of the P53 gene occurred in 3 out of the 7 cases. The mutant rate was 42. 9%. |
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| Keywords: | Hepatocellular Carcinoma P53 gene PCR-RFLP |
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